What happened to the program? 

CRISPR Cas9
CRISPR Cas9

In the first decades after WWII, radiation breeding was seen as a promising new field both for geneticists working on the basic mechanisms of plant heredity as well as for professional plant breeders who hoped for new commercial and agricultural varieties. In the early 1950s, Brookhaven engaged in an international cooperation “by means of which plant breeders and geneticists throughout the world have been able to make use of the radiation facilities at Brookhaven in their attempts at crop improvement,” according to BNL’s annual report for 1957. More than 100 institutions were involved. As the lab’s annual report described in 1955, “Brookhaven continues to perform the irradiation, act in an advisory capacity, and collect and analyze the data. The individual institutions initiate the program, grow the material, and screen it for the desired mutations.” The program was called the Cooperative Radiation Mutation Program, and it went on for several decades. 

Ethyl methanesulfonate

In fact, scientists engaged in mutation breeding still use radiation exposure to induce mutations in plants and other organisms. Radiation, though, is just one of the tools that they have at their disposal. Other methods include exposure to chemical mutagens such as ethyl methanesulfonate (EMS). Brookhaven scientists were using EMS to induce mutations in plants by the mid-1960s for example. Compared to the techniques that were available by the late 1960s and 1970s to induce and manipulate genetic changes in experimental organisms, the gamma field of the 1950s was a fairly blunt instrument, and for this reason it was ultimately abandoned in favor of these other tools. With the discovery of recombinant DNA technology in the 1970s and CRISPR-cas9 in 2009, our ability to cut and paste genetic material has only increased. But although the tools have changed, scientists still have some of the same goals as they did seventy years ago — crop improvement and a better understanding of genetics, to name only two. They also face some of the same questions and challenges. The ability to manipulate genes gives humans a lot of power. How and for what purposes that power should be used were important questions back in the 1950s and remain so today.

Photo Credit: (CRISPR) NIH Image Gallery from Bethesda, Maryland, USA, Public domain, via Wikimedia Commons; (Ethyl methanesulfonate) Jynto and Ben Mills, Public domain, via Wikimedia Commons

Plants need nitrogen to grow, but a significant portion of the nitrogen in fertilizers is not absorbed by the soil or used by the growing plants. Rather, it washes away into waterways, rivers, and the ocean. This in turn has had devastating effects on marine life. In some areas, excessive nitrogen in the oceans has caused algae blooms that kill wildlife, make it dangerous for people to consume fish or shellfish or in some cases even swim in affected waters. This problem isn’t limited to poorer countries. Nitrogen pollution is a serious problem here on Long Island. In our case, the nitrogen comes primarily from septic tanks and cesspools, although nitrogen from agricultural fertilizers also plays a role. Nitrogen pollution in the waters around Long Island has hampered fishing, made it dangerous to eat seafood from some areas, and caused environmental changes that make coastal areas more prone to flooding.